Hepatitis C, an infectious disease that can cause inflammation and organ failure in the liver, appeared to have different effects on different people. To this day it is not certain why some people are very susceptible to hepatitis virus infection, while others are resistant.
The scientists believe the genetic differences that affect the different responses of each person against the hepatitis virus can be detected by studying the cells of the liver in people who are different. However, liver cells so it is difficult to obtain, and very difficult to be grown in a dish in laboratorium, because they tend to lose their normal structure and function when removed from the body.
Now researchers from the Massachusetts Institute of Technology, Rockefeller University, and the Medical College of Wisconsin have discovered how to study the liver cells, namely by producing artificial liver cells made from the induction of pluripotent stem cells or iPSCs.
By creating an artificial liver cells, they can study the different responses of each person against viral hepatitis. The resulting artificial liver cells and cells infected with hepatitis C in accordance with the desired research goals.
"These methods make it easier for scientists studying why people respond in different infectious diseases," said one researcher who joined the team.
This trial is the first time for scientists to create an infection in cells derived from iPSCs. The new technique presented in the journal Proceedings of the National Academy of Sciences can also be used to produce "personalized medicine" for patients with hepatitis C.
Doctors can test the effectiveness of different drugs in tissues derived from patients who were treated. In this way, other researchers said, doctors can tailor a suitable therapy for each patient. *** [MIT | MAHARDIKA SATRIA HADI | KORAN TEMPO 3789]
The scientists believe the genetic differences that affect the different responses of each person against the hepatitis virus can be detected by studying the cells of the liver in people who are different. However, liver cells so it is difficult to obtain, and very difficult to be grown in a dish in laboratorium, because they tend to lose their normal structure and function when removed from the body.
Now researchers from the Massachusetts Institute of Technology, Rockefeller University, and the Medical College of Wisconsin have discovered how to study the liver cells, namely by producing artificial liver cells made from the induction of pluripotent stem cells or iPSCs.
By creating an artificial liver cells, they can study the different responses of each person against viral hepatitis. The resulting artificial liver cells and cells infected with hepatitis C in accordance with the desired research goals.
"These methods make it easier for scientists studying why people respond in different infectious diseases," said one researcher who joined the team.
This trial is the first time for scientists to create an infection in cells derived from iPSCs. The new technique presented in the journal Proceedings of the National Academy of Sciences can also be used to produce "personalized medicine" for patients with hepatitis C.
Doctors can test the effectiveness of different drugs in tissues derived from patients who were treated. In this way, other researchers said, doctors can tailor a suitable therapy for each patient. *** [MIT | MAHARDIKA SATRIA HADI | KORAN TEMPO 3789]
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